The Portuguese, 55, won the FA Cup and the Europa League at Old Trafford.
But United are sixth in the Premier League, 19 points behind leaders Liverpool, who beat them 3-1 on Sunday.
“A caretaker-manager will be appointed until the end of the season while the club conducts a thorough recruitment process for a new, full-time manager,” United said in a statement.
“The club would like to thank Jose for his work during his time at Manchester United and to wish him success in the future,”
Lyon’s manager Bruno Genesio could replace Jose Mourinho at Manchester United. The Frenchman is currently on his way to England to finalize the deal, league sources tell Libero Lyon.
Here are his stats at united:
Jose Mourinho has been sacked by
58.3 Win %
2016 Community Shield